Monoclonal CD154 antibody, Anti-CD154 antibody, CD154, CD 154 antibody, TRAP antibody, Tnfsf5 antibody, CD-154 antibody, CD-154, CD40L antibody, CD 154
Specificity
Human
Cross Reactivity
Cynomolgus Monkey
Applications
FC, Functional Assay, IHC
Assay Information
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest.
Store at 2-8 deg C. Do not freeze. Protect from light.
General Information
Biological Significance
The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand. CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the cynomolgus monkey CD154.