CD23 antibody (10R-6366)
Mouse monoclonal CD23 antibody
Overview
Overview
| Synonyms | Monoclonal CD23 antibody, Anti-CD23 antibody, CD-23 antibody, FceRII antibody, CD 23 antibody, IGEBF antibody, CD 23, Low Affinity IgE Receptor antibody, FcER2 antibody, CD-23, CD23 |
|---|---|
| Specificity | Human |
| Applications | FC, Functional Assay, IHC |
| Assay Information | A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest |
Images
Flow Cytometric analysis using CD23 antibody (10R-6366)
Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG1 kappa Isotype Control (open histogram) or 0.25 ug of CD23 antibody (filled histogram) followed by Anti-Mouse IgG (FITC). Cells in the lymphocyte gate were used for analysis.
Specifications
| Host | Mouse |
|---|---|
| Clone | EBVCS2 |
| Isotype | IgG1 |
| Method of Purification | CD23 antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
| Concentration | 500 ug/ml |
Usage & Assay Information
| Usage Recommendations | FC: = 0.25 ug/test |
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Storage & Safety
| Storage | Store at 2-8 deg C. Do not freeze. Protect from light. |
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General Information
| Biological Significance | The EBVCS2 monoclonal antibody reacts with human CD23, a 45 kDa type II transmembrane glycoprotein. CD23 is expressed on mature B cells, mantle zone B cells, follicular dendritic cells and at low levels on T, NK, langerhans cells and platelets. Expression of CD23 is upregulated upon B cell activation, and soluble forms of the antigen have been reported to be biologically active. CD23 is a low affinity receptor for IgE and is thought to play a role in the regulation of IgE response and B cell activation. CD21 and the alpha subunit of CD11b and CD11c bind to CD23. |
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