CD38 antibody (10R-6389)
Rat monoclonal CD38 antibody
Overview
Overview
| Synonyms | Monoclonal CD38 antibody, Anti-CD38 antibody, CD38, CD-38 antibody, T10 antibody, CD 38, ADP-Ribosyl Cyclase antibody, CD-38, CD 38 antibody |
|---|---|
| Specificity | Mouse |
| Applications | FC |
| Assay Information | Atest is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest. |
Images
Flow Cytometric analysis using CD38 antibody (10R-6389)
Staining of BALB/c splenocytes with 0.06 ug of Rat IgG2a Isotype Control (open histogram) or 0.06 ug CD38 antibody (filled histogram) followed by Anti-Rat IgG (FITC). Total viable cells were used for analysis.
Specifications
| Host | Rat |
|---|---|
| Clone | 90 |
| Isotype | IgG2a kappa |
| Method of Purification | CD38 antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
| Concentration | 500 ug/ml |
Usage & Assay Information
| Usage Recommendations | FC: = 0.5 ug/test |
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Storage & Safety
| Storage | Store at 2-8 deg C. Do not freeze. Protect from light. |
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General Information
| Biological Significance | The 90 monoclonal antibody reacts with the mouse CD38 molecule, an ~42 kDa type II transmembrane protein. CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. Its expression is reported on a subpopulation of thymocytes, mature T cells, and NK cells. Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhanced by co-signals such as IL-4 and LPS. CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a role in lymphocyte activation and differentiation. |
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