CD38 antibody (10R-6389)

Rat monoclonal CD38 antibody

Synonyms Monoclonal CD38 antibody, Anti-CD38 antibody, CD38, CD-38 antibody, T10 antibody, CD 38, ADP-Ribosyl Cyclase antibody, CD-38, CD 38 antibody
Specificity Mouse
Applications FC
Assay Information Atest is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest.

Images

Flow Cytometric analysis using CD38 antibody (10R-6389)

Staining of BALB/c splenocytes with 0.06 ug of Rat IgG2a Isotype Control (open histogram) or 0.06 ug CD38 antibody (filled histogram) followed by Anti-Rat IgG (FITC). Total viable cells were used for analysis.

Specifications

Host Rat
Clone 90
Isotype IgG2a kappa
Method of Purification CD38 antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations FC: = 0.5 ug/test

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The 90 monoclonal antibody reacts with the mouse CD38 molecule, an ~42 kDa type II transmembrane protein. CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. Its expression is reported on a subpopulation of thymocytes, mature T cells, and NK cells. Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhanced by co-signals such as IL-4 and LPS. CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a role in lymphocyte activation and differentiation.

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Images

  • Flow Cytometric analysis using CD38 antibody (10R-6389) | Staining of BALB/c splenocytes with 0.06 ug of Rat IgG2a Isotype Control (open histogram) or 0.06 ug CD38 antibody (filled histogram) followed by Anti-Rat IgG (FITC). Total viable cells were used for analysis.

Availability: In stock

Price: €143.15

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Price: €143.15
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