CD4 antibody (10R-6332)
Rat monoclonal CD4 antibody
Overview
Overview
| Synonyms | Monoclonal CD4 antibody, Anti-CD4 antibody, CD4, CD-4, Ly-4 antibody, L3T4 antibody, CD-4 antibody, CD 4, CD 4 antibody |
|---|---|
| Specificity | Mouse |
| Applications | ELISA |
Images
Flow Cytometric analysis using CD4 antibody (10R-6332)
Staining of C57Bl/6 splenocytes with 0.06 ug of Rat IgG2b Isotype Control (open histogram) or 0.06 ug of CD4 antibody (filled histogram) followed by Anti-Rat IgG (FITC). Total viable cells were used for analysis.
Specifications
| Host | Rat |
|---|---|
| Clone | GK1.5 |
| Isotype | IgG2b kappa |
| Method of Purification | CD4 antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
| Concentration | 500 ug/ml |
Storage & Safety
| Storage | Store at 2-8 deg C. Do not freeze. Protect from light. |
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General Information
| Biological Significance | The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5. |
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