CD40LG protein (His tag) (80R-1774)
Purified recombinant Human CD40LG protein
|Synonyms||CD-40LG, IGM protein, CD154 protein, TNFSF5 protein, CD40L protein, IMD3 protein, CD40 ligand protein, CD-40LG BLGocking Peptide, CD 40LG BLGocking Peptide, gp39; hCD40L protein, TRAP protein, CD40LG, CD 40LG, T-BAM protein, HIGM1 protein|
Coomassie Blue stained SDS-PAGE of CD40LG protein (His tag) (80R-1774)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||113-261 amino acids: MGSSHHHHHH SSGLVPRGSH MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LCLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL|
|Grade & Purity||> 95% pure|
|Molecular Weight||18.3 kDa (169aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 40% glycerol and 0.2M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CD40 ligand, also known as CD40LG, is a member of the TNF superfamily and is expressed on activated T cells. CD40LG is expressed as a soluble cytokine as well as a homotrimeric type II transmembrane protein. It has been reported to be important for B cell costimulation following binding of its receptor, CD40. Mutations in the gene encoding for CD154 are implicated in hyper-IgM immunodeficiency syndrome type 1. Recombinant human CD40LG protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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