CD44 antibody (10R-CD44ePG)
Rat monoclonal CD44 antibody
Overview
Overview
| Synonyms | Monoclonal CD44 antibody, Anti-CD44 antibody, CD 44 antibody, Pgp1 antibody, HCAM antibody, CD44, CD 44, H-CAM antibody, CD-44, CD-44 antibody, chondroitin sulfate proteoglycan 8 antibody, MDU2 antibody, CSPG8 antibody, IN antibody, CD-44 antibody, CD44R antibody, MDU3 antibody, hematopoietic cell E- and L-selectin ligand antibody |
|---|---|
| Specificity | Pig |
| Cross Reactivity | Bovine, dog, horse, goat, sheep |
| Applications | FC, IHC-F, IHC-P, IP |
| Immunogen | CD44 antibody was raised in rat using purified porcine wCD44 as the immunogen. |
Images
Immunohistochemical staining using CD44 antibody (10R-CD44ePG)
Representative images of immunohistology of ovine synovium from NOC (A–F), saline-treated (G–I), Hyalgan-treated (J–L) or HYADD 4-G treated (M–O) joints stained with negative control antibodies (A–C) or antibodies to CD44 (D, G, J, M); CTGF (E, H, K, N) or iNOS (F, I, L, O). Bar represents 100 um for all images, which were captured at ×200 magnification.
Specifications
| Host | Rat |
|---|---|
| Clone | MAC329 |
| Isotype | IgG1 |
| Form & Buffer | Concentrated tissue culture supernatant supplied in 0.2M tris-HCl pH7.4,5-10% FCS, and 0.09% NaN3. |
| Concentration | Batch dependent - please inquire should you have specific requirements |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by end user |
|---|
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|---|
| Biohazard Information | This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
General Information
| Biological Significance | CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). The HCELL glycoform was originally discovered on human hematopoietic stem cells and leukemic blasts, and was subsequently identified on cancer cells. |
|---|
Reviews
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product