CD44 antibody (10R-CD44ePG)

Rat monoclonal CD44 antibody

Synonyms Monoclonal CD44 antibody, Anti-CD44 antibody, CD 44 antibody, Pgp1 antibody, HCAM antibody, CD44, CD 44, H-CAM antibody, CD-44, CD-44 antibody, chondroitin sulfate proteoglycan 8 antibody, MDU2 antibody, CSPG8 antibody, IN antibody, CD-44 antibody, CD44R antibody, MDU3 antibody, hematopoietic cell E- and L-selectin ligand antibody
Specificity Pig
Cross Reactivity Bovine, dog, horse, goat, sheep
Applications FC, IHC-F, IHC-P, IP
Immunogen CD44 antibody was raised in rat using purified porcine wCD44 as the immunogen.

Images

Flow cytometric assay using CD44 antibody (10R-CD44ePG)

Flow cytometry analysis of activation molecules expressed by hepatic and splenic T cells isolated from dogs naturally infected with Leishmania chagasi. Shown is a correlative display of CD45RO-phycoerythrin (PE) and CD44-fluorescein isothiocyanate (FITC) in the livers and spleens of asymptomatic and symptomatic dogs. Notice the different proportions of central memory (CD44lo, CD45ROhi) (R2), activated effector memory (CD44hi, CD45ROhi) (R3), and naive (CD44lo, CD45RO−) T cells (R4) in the livers and spleens of both groups. Results are from a single representative dog for each group.

Specifications

Host Rat
Clone MAC329
Isotype IgG1
Form & Buffer Concentrated tissue culture supernatant supplied in 0.2M tris-HCl pH7.4,5-10% FCS, and 0.09% NaN3.
Concentration Batch dependent - please inquire should you have specific requirements

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). The HCELL glycoform was originally discovered on human hematopoietic stem cells and leukemic blasts, and was subsequently identified on cancer cells.

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Images

  • Flow cytometric assay using CD44 antibody (10R-CD44ePG) | Flow cytometry analysis of activation molecules expressed by hepatic and splenic T cells isolated from dogs naturally infected with Leishmania chagasi. Shown is a correlative display of CD45RO-phycoerythrin (PE) and CD44-fluorescein isothiocyanate (FITC) in the livers and spleens of asymptomatic and symptomatic dogs. Notice the different proportions of central memory (CD44lo, CD45ROhi) (R2), activated effector memory (CD44hi, CD45ROhi) (R3), and naive (CD44lo, CD45RO−) T cells (R4) in the livers and spleens of both groups. Results are from a single representative dog for each group.
  • Immunohistochemical staining using CD44 antibody (10R-CD44ePG) | Representative images of immunohistology of ovine synovium from NOC (A–F), saline-treated (G–I), Hyalgan-treated (J–L) or HYADD 4-G treated (M–O) joints stained with negative control antibodies (A–C) or antibodies to CD44 (D, G, J, M); CTGF (E, H, K, N) or iNOS (F, I, L, O). Bar represents 100 um for all images, which were captured at ×200 magnification.

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Price: €446.90
Size: 2 ml
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