CDC45L antibody (70R-13279)
Affinity purified Rabbit polyclonal CDC45L antibody
Overview
Overview
| Synonyms | Polyclonal CDC45L antibody, Anti-CDC45L antibody, CDC45-related protein antibody, CDCL 45 antibody, CDCL-45 antibody, CDC45L antibody, PORC-PI-1 antibody, CDC45 cell division cycle 45 homolog antibody, cell division control protein 45 homolog antibody, CDC45 antibody, CDCL-45, human CDC45 antibody, CDCL 45, CDC45L2 antibody, cell division cycle 45 homolog (S. cerevisiae) antibody, cell division cycle 45-like 2 antibody, CDC45L |
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| Cross Reactivity | Human |
| Applications | ICC, IF, WB |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | CDC45L antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 66 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:200, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. |
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