CDK4 antibody (10R-7838)
Rabbit monoclonal CDK4 antibody
Overview
Overview
| Synonyms | Monoclonal CDK4 antibody, Anti-CDK4 antibody, Cell division protein kinase 4 antibody, CMM3 antibody, Crk3 antibody, CMM 3 antibody, p34 cdk4 antibody, CDK4, CDK 4, PSK J3 antibody, MGC14458 antibody, Cyclin dependent kinase 4 antibody, CDK-4, CDK 4 antibody, CDK-4 antibody, Cyclin-dependent kinase 4 antibody, Cell division kinase 4 antibody, PSK-J3 antibody , Melanoma cutaneous malignant 3 antibody |
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| Applications | ICC, WB |
| Immunogen | CDK4 antibody was raised in mouse using recombinant human Cdk4 protein as the immunogen |
Specifications
| Host | Mouse |
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| Clone | IML-4 |
| Isotype | IgG2a |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Cyclin-dependent kinase activity is regulated by T-loop phosphorylation, by the abundance of their cyclin partners and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase. The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. In HeLa cells, upon UV irradiation, upregulation of p16 INK4a association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclinD3 activity in progression through G2-phase of the cell cycle. |
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