CDK4 antibody (10R-7838)

Rabbit monoclonal CDK4 antibody

Synonyms Monoclonal CDK4 antibody, Anti-CDK4 antibody, Cell division protein kinase 4 antibody, CMM3 antibody, Crk3 antibody, CMM 3 antibody, p34 cdk4 antibody, CDK4, CDK 4, PSK J3 antibody, MGC14458 antibody, Cyclin dependent kinase 4 antibody, CDK-4, CDK 4 antibody, CDK-4 antibody, Cyclin-dependent kinase 4 antibody, Cell division kinase 4 antibody, PSK-J3 antibody , Melanoma cutaneous malignant 3 antibody
Applications ICC, WB
Immunogen CDK4 antibody was raised in mouse using recombinant human Cdk4 protein as the immunogen

Specifications

Host Mouse
Clone IML-4
Isotype IgG2a
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance Cyclin-dependent kinase activity is regulated by T-loop phosphorylation, by the abundance of their cyclin partners and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase. The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. In HeLa cells, upon UV irradiation, upregulation of p16 INK4a association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclinD3 activity in progression through G2-phase of the cell cycle.

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Availability: In stock

Price: €220.86
Size: 100 ug
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