CDK5 antibody (10R-7445)
Mouse monoclonal CDK5 antibody
Overview
Overview
| Synonyms | Monoclonal CDK5 antibody, Anti-CDK5 antibody, Cyclin dependent kinase 5 antibody, TPKII catalytic subunit antibody, Cell division protein kinase 5 antibody, Protein kinase CDK5 splicing antibody, Tau protein kinase II catalytic subunit antibody, CDK5, PSSALRE antibody, Crk6 antibody, Serine threonine protein kinase PSSALRE antibody, CDK-5, CDK 5, CDK 5 antibody, CDK-5 antibody |
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| Cross Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IP, WB |
| Immunogen | CDK5 antibody was raised in Mouse using His-tagged recombinant human CDK5 protein purified from Baculovirus expressed insect cells as the immunogen. |
Specifications
| Host | Mouse |
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| Clone | 8A1 |
| Isotype | IgG2b kappa |
| Method of Purification | CDK5 antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in PBS buffer (without mg2+ and Ca2+), pH 7.4, 150mM NaCl and 50% glycerol. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | ELISA: WB: 1:1000-2000 IP 2 ul/400 ul cell lysates |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.. |
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General Information
| Biological Significance | Cyclin-dependent kinase-5 (CDK5) is a member of the cyclindependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in kidney, testes, and ovary. And Its activity is detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits called p35 and p39. The two activators regulate the spatial and temporal expression of active Cdk5 to restrict its activity primarily to post-mitotic neurons. |
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