CGRP antibody (20R-CP007)

Guinea Pig polyclonal CGRP antibody

Synonyms Polyclonal CGRP antibody, Anti-CGRP antibody, Calcitonin gene-related peptide antibody
Specificity Human CGRP
Cross Reactivity Human, rat
Applications IF, IHC-F, IHC-P
Immunogen CGRP antibody was raised in guinea pig using synthetic human calcitonin gene related peptide as the immunogen.

Specifications

Host Guinea Pig
Isotype IgG1
Form & Buffer Supplied as a lyophilized powder. Dissolve the antiserum in 50 – 100 ul distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.1% NaN3.

Usage & Assay Information

Usage Recommendations IF: 1:1,000-1:1200

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance The CGRP-sequence was predicted from the corresponding mRNA. CGRP is present in the C-cells of the thyroid and in nerves, in both brain and periphery, particularly within the sensory system. CGRP is a potent vasodilator, probably involved in neurogenic inflammation. Medullary carcinomas of the thyroid contain large amounts of CGRP. Absorption with 10 – 100 ug CGRP per ml diluted antiserum abolishes the staining while calcitonin, does not. Cross-reacts with amylin (IAPP)

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