CHEK2 Blocking Peptide (33R-8747)
A synthetic peptide for use as a blocking control in assays to test for specificity of CHEK2 antibody, catalog no. 70R-7835
Overview
Overview
| Synonyms | CHEK2 control peptide, CHEK2 antibody Blocking Peptide, Anti-CHEK2 Blocking Peptide, CHK2 checkpoint homolog, S. pombe Blocking Peptide, CDS1 Blocking Peptide, CHK2 Blocking Peptide, HuCds1 Blocking Peptide, LFS2 Blocking Peptide, PP1425 Blocking Peptide, RAD53 Blocking Peptide, CHEK2, CHEK-2, CHEK 2, CHEK-2 Blocking Peptide, CHEK 2 Blocking Peptide |
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| Protein Type | Synthetic |
| Applications | IHC, WB |
Specifications
| Residues | SRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQ |
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| Molecular Weight | 65 kDa |
| Form & Buffer | Lyophilized powder. Add 100ul of distilled water for a final peptide concentration is 1 mg/ml. |
Storage & Safety
| Storage | Store at -20 deg C long term. Avoid repeat freeze-thaw cycles. |
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General Information
| Biological Significance | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. |
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