Chitotriosidase antibody (70R-12593)
Affinity purified Rabbit polyclonal Chitotriosidase antibody
Overview
Overview
| Synonyms | Polyclonal Chitotriosidase antibody, Anti-Chitotriosidase antibody, CHI3 antibody, plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase antibody, chitinase-1 antibody, CHIT antibody, FLJ00314 antibody, CHIT1 antibody, MGC125322 antibody, chitotriosidase-1 antibody |
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| Cross Reactivity | Human |
| Applications | WB |
| Immunogen | Chitotriosidase antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 216 and 463 of Chitotriosidase |
Images
Western blot analysis using Chitotriosidase antibody (70R-12593)
Western blot analysis of 30 ug of whole cell lysate (A: Hela) using a 10 % SDS PAGE gel and Chitotriosidase antibody at a dilution of 1:1000
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Chitotriosidase antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 52 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. |
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