Chk1 antibody (20R-2911)
Rabbit polyclonal Chk1 antibody
Overview
Overview
| Synonyms | Polyclonal Chk1 antibody, Anti-Chk1 antibody, CHEK1 antibody, checkpoint kinase 1 antibody, 2720 antibody, BOS_24586 antibody, C85740 antibody, cell cycle checkpoint kinase antibody, CH211-257I19.3 antibody, checkpoint kinase-1 antibody, checkpoint kinase 1 homolog antibody, Checkpoint antibody, S. pombe antibody, homolog of antibody, 1 antibody, chk1 antibody, CHK1 checkpoint homolog antibody, CHK1 checkpoint homolog (S. pombe) antibody, Chk1 checkpoint kinase antibody, Chk1-S antibody, rad27 antibody, rad27 homolog antibody, serine/threonine-protein kinase Chk1 antibody, xChk1 antibody |
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| Cross Reactivity | Human |
| Applications | WB |
| Immunogen | Chk1 antibody was raised in Rabbit using a synthetic target peptide as the immunogen |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Chk1 antibody was purified by Protein A affinity chromatography |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:2000, |
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Storage & Safety
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | Check point kinase 1 (Chk1) is a serine / threonine protein kinase and a key mediator in the DNA damage-induced checkpoint network. Chk1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of Chk1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, Chk1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient. |
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