CHMP2A protein (His tag) (80R-1186)
Purified recombinant Human CHMP2A protein
|Synonyms||Putative breast adenocarcinoma marker BC2 protein, VPS2A protein, Vacuolar protein sorting associated protein 2 1., BC2 protein, CHMPA 2 protein, CHMP2A, putative breast adenocarcinoma marker protein, VPS2 protein, CHMPA 2, CHMPA-2 protein, BC-2 protein, CHMPA-2, CHMP2 protein, hVps2 1 protein, Chromatin modifying protein 2A Charged multivesicular body protein 2a Vps2 1 protein|
Coomassie Blue stained SDS-PAGE of CHMP2A protein (His tag) (80R-1186)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-222 amino acids: MGSSHHHHHH SSGLVPRGSH MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD|
|Grade & Purity||> 90% pure|
|Molecular Weight||27.2 kDa (242aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 0.1M NaCl, 1mM DTT, and 30% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CHMP2A, also known as chromatin modifying protein 2A, belongs to the SNF7 family and it is a component of the ESCRT III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. Recombinant CHMP2A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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