CIRBP protein (His tag) (80R-1790)
Purified recombinant Human CIRBP protein
|Synonyms||Cold inducible RNA-binding protein, A18HNRNP protein, CIRP protein|
Coomassie Blue stained SDS-PAGE of CIRBP protein (His tag) (80R-1790)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-172 amino acids: MGSSHHHHHH SSGLVPRGSH MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE|
|Grade & Purity||> 95% pure|
|Molecular Weight||20.8 kDa (192aa) confirmed by MALDI-TOF|
|Form & Buffer||Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.2M NaCl|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Cold inducible RNA-binding protein, also known as CIRBP, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It is localizes to the nucleus and contains one RRM (RNA recognition motif) domain. Expressed ubiquitously, CIRBP is thought to play an essential role in the suppression of cellular proliferation in response to UV irradiation or extreme cold. Recombinant human CIRBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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