CITED2 protein (His tag) (80R-1155)
Purified recombinant Human CITED2 protein
|Synonyms||Cbp/p300-interacting transactivator 2 Cbp/p300 interacting transactivator 2 protein, MRG1 protein, Cbp/p300-interacting transactivator 2 protein, CITED2, , CITED 2, CITED-2, CITED-2 protein, P35SRJ protein, CITED2 protein, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy terminal domain 2 protein, MRG 1 protein, CITED 2 protein, MSG related protein 1 protein|
Coomassie Blue stained SDS-PAGE of CITED2 protein (His tag) (80R-1155)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-270 amino acids: MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ NEFDFMTDFV CKQQPSRVSC LEHHHHHH|
|Grade & Purity||> 90% pure|
|Molecular Weight||29.5 kDa (278 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 0.1M NaCl, 50% glycerol, and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||CITED2 is an important transcriptional cofactor involved in multiple organ development. It is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1alpha through its competitive binding with HIF-1alpha to CBP/p300. CITED2 is necessary for mouse fetal liver hematopoiesis and is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Recombinant CITED2 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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