Clostridium difficile Toxin A protein (30-1863)

Purified Native Clostridium difficile Toxin A protein (ribotype 027)

Synonyms Clostridium difficile Toxin A antigen, C difficile toxin A protein, TcdA protein, Toxin A protein
Species Viral
Protein Type Native

Specifications

Source Native toxin A purified from hypervirulent C. difficile strain R20291 (Stoke Mandeville) ribotype 027
Grade & Purity > 95% pure
Form & Buffer Supplied in 0.05M hepes, 0.15M NaCl, 5% sucrose
Concentration 100 ug/ml

Storage & Safety

Storage Store at 4 deg C

General Information

Product Use Clostridium difficile Toxin A protein for use in the research laboratory
Biological Significance Clostridium difficile Toxin A is the better characterized of the two LCTs produced by C. difficile. Collectively, TcdA and TcdB are directly responsible for the increasingly common and serious human gastrointestinal disease caused when antibiotic treatment enables C. difficile to out-compete commensal gut microflora. Recently, the crystal structure of a C-terminal fragment of TcdA has been solved, revealing a solenoid-like structure, which consists of 32 short repeats with 15–21 residues and seven long repeats with 30 residues.
Implications in Disease C. difficile toxin A causes the colon to become inflamed (colitis) and sometimes may form patches of raw tissue that can bleed or produce pus (pseudomembranous colitis). Signs and symptoms of severe infection include: Watery diarrhea 10 to 15 times a day, Abdominal cramping and pain, which may be severe, Fever, Blood or pus in the stool, Nausea, Dehydration, Loss of appetite, Weight loss, Swollen abdomen, Kidney failure and increased white blood cell count.

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