Clostridium difficile Toxin A protein (30-1865)
Purified Native Clostridium difficile Toxin A protein (ribotype 078)
Overview
Overview
| Synonyms | Clostridium difficile Toxin A antigen, C difficile toxin A protein, TcdA protein, Toxin A protein |
|---|---|
| Species | Viral |
| Protein Type | Native |
Specifications
| Source | Native toxin A purified from hypervirulent C. difficile strain 210708 ribotype 078 |
|---|---|
| Grade & Purity | > 90% pure |
| Form & Buffer | Supplied in 0.05M hepes, 0.15M NaCl, 5% sucrose |
| Concentration | 100 ug/ml |
Storage & Safety
| Storage | Store at 4 deg C |
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General Information
| Product Use | Clostridium difficile Toxin A protein for use in the research laboratory |
|---|---|
| Biological Significance | Clostridium difficile is a common nosocomial pathogen and a major cause of infectious diarrhea in hospitalized patients. Colonization with C. difficile is associated with a wide spectrum of clinical presentations ranging from asymptomatic carriage to fulminant pseudomembranous colitis. |
| Implications in Disease | C. difficile toxin A causes the colon to become inflamed (colitis) and sometimes may form patches of raw tissue that can bleed or produce pus (pseudomembranous colitis). Signs and symptoms of severe infection include: Watery diarrhea 10 to 15 times a day, Abdominal cramping and pain, which may be severe, Fever, Blood or pus in the stool, Nausea, Dehydration, Loss of appetite, Weight loss, Swollen abdomen, Kidney failure and increased white blood cell count. |
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