Clostridium difficile Toxin B protein (30-1866)

Purified Native Clostridium difficile Toxin B protein (ribotype 078)

Synonyms Clostridium difficile Toxin B antigen, C difficile toxin B protein, TcdB protein, Toxin B protein
Species Viral
Protein Type Native

Specifications

Source Native toxin B purified from hypervirulent C. difficile strain 210708 ribotype 078
Grade & Purity > 90% pure
Form & Buffer Supplied in 0.05M hepes, 0.15M NaCl, 5% sucrose
Concentration 100 ug/ml

Storage & Safety

Storage Store at 4 deg C

General Information

Product Use Clostridium difficile Toxin B protein for use in the research laboratory
Biological Significance Two structurally similar toxins denoted as Clostridium difficile Toxin A (308 kDa) and Clostridium difficile Toxin B (270 kDa) are the main virulence determinants associated with Clostridium difficile-associated disease (CDAD) and most pathogenic strains of C. difficile produce both toxins (A+B+). Both of these large toxins are glucosyltransferases that catalyze the monoglucosylation of threonine 35/37 of small GTP-binding proteins Rho, Rac, and Cdc42 within target cells, and thus modulate several physiological cellular events resulting in cell death.
Implications in Disease Clostridium difficile Toxin B is proinflammatory and cytotoxic, causing disruption of the actin cytoskeleton and impairment of tight junctions in human intestinal epithelial cells, with resulting fluid accumulation and extensive damage to the large intestine.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price From: Price: €548.06
Price From: Price: €548.06
Shipping
View Our Distributors