Clostridium difficile Toxin B protein (30-1866)
Purified Native Clostridium difficile Toxin B protein (ribotype 078)
Overview
Overview
| Synonyms | Clostridium difficile Toxin B antigen, C difficile toxin B protein, TcdB protein, Toxin B protein |
|---|---|
| Species | Viral |
| Protein Type | Native |
Specifications
| Source | Native toxin B purified from hypervirulent C. difficile strain 210708 ribotype 078 |
|---|---|
| Grade & Purity | > 90% pure |
| Form & Buffer | Supplied in 0.05M hepes, 0.15M NaCl, 5% sucrose |
| Concentration | 100 ug/ml |
Storage & Safety
| Storage | Store at 4 deg C |
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General Information
| Product Use | Clostridium difficile Toxin B protein for use in the research laboratory |
|---|---|
| Biological Significance | Two structurally similar toxins denoted as Clostridium difficile Toxin A (308 kDa) and Clostridium difficile Toxin B (270 kDa) are the main virulence determinants associated with Clostridium difficile-associated disease (CDAD) and most pathogenic strains of C. difficile produce both toxins (A+B+). Both of these large toxins are glucosyltransferases that catalyze the monoglucosylation of threonine 35/37 of small GTP-binding proteins Rho, Rac, and Cdc42 within target cells, and thus modulate several physiological cellular events resulting in cell death. |
| Implications in Disease | Clostridium difficile Toxin B is proinflammatory and cytotoxic, causing disruption of the actin cytoskeleton and impairment of tight junctions in human intestinal epithelial cells, with resulting fluid accumulation and extensive damage to the large intestine. |
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