CMPK1 protein (His tag) (80R-1740)
Purified recombinant Human CMPK1 protein
|Synonyms||CMPK-1, UMK protein, UMP-CMPK protein, CMK protein, CMPK-1 protein, UMP-CMP kinase protein, CMPK protein, UMPK protein, CMPK 1, RP11-511I2.1 protein, CMPK1, CMPK 1 protein|
Coomassie Blue stained SDS-PAGE of CMPK1 protein (His tag) (80R-1740)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-228 amino acids: MGSSHHHHHH SSGLVPRGSH MLSRCRSGLL HVLGLSFLLQ TRRPILLCSP RLMKPLVVFV LGGPGAGKGT QCARIVEKYG YTHLSAGELL RDERKNPDSQ YGELIEKYIK EGKIVPVEIT ISLLKREMDQ TMAANAQKNK FLIDGFPRNQ DNLQGWNKTM DGKADVSFVL FFDCNNEICI ERCLERGKSS GRSDDNRESL EKRIQTYLQS TKPIIDLYEE MGKVKKIDAS KSVDEVFDEV VQIFDKEG|
|Grade & Purity||> 90% pure|
|Molecular Weight||28.0 kDa (248aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 1mM DTT and 100mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CMPK1, also known as UMP-CMP kinase and deoxycytidylate kinase, is an enzyme that catalyzes the phosphoryl transfer from ATP to UMP, CMP and dCMP. This enzymatic reaction leads to the formation of ADP and the corresponding nucleoside diphosphate, which are required for cellular nucleic acid synthesis. It also plays an important role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. Recombinant human CMPK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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