CMV protein (80-1543)

Purified Recombinant CMV protein (gH pentamer complex) (His tag)

Synonyms CMV antigen, Cytomegalovirus antigen, Cytomegalovirus protein
Species Viral
Protein Type Recombinant

Specifications

Expression System 293 cells
Grade & Purity > 95% pure
Tag/Conjugate His tag
Form & Buffer Supplied in DPBS, pH 7.4
Concentration 1-1.5 mg/ml

Storage & Safety

Storage Store at -80 deg C

General Information

Product Use CMV protein for use in the research laboratory
Biological Significance The Cytomegalovirus gH Pentamer Complex is expressed on all wildtype hCMV strains but is notably missing from laboratory strains such as AD169. Receptor-mediated viral entry into endothelial cells requires a functional gH pentameric complex, and this complex is one of the primary targets for antiviral antibodies in infected individuals.
Implications in Disease Most people infected with CMV who are otherwise healthy experience few if any symptoms. When first infected, some adults may have symptoms similar to mononucleosis, including fatigue, fever and muscle aches. An illness resembling infectious mononucleosis is the most common presentation of CMV in people with weakened immune systems (immunocompromised). CMV also can attack specific organs. Signs and symptoms may include: Fever, Pneumonia, Diarrhea, Ulcers in the digestive tract, Hepatitis, Inflammation of the brain (encephalitis), Behavioral changes, Seizures, Coma, Visual impairment and blindness. Newborns infected with CMV in the womb (congenital CMV), babies who become infected during birth or shortly after birth (perinatal CMV) such as through breast-feeding and people with weakened immune systems are more at risk of developing signs and symptoms than are healthy adults.

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Availability: In stock

Price From: Price: €363.19
Price From: Price: €363.19
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