COMMD1 protein (His tag) (80R-1392)
Purified recombinant Human COMMD1 protein
|Synonyms||MURR-1, C2orf5 protein, MURR1 protein, COMMD-1 protein, COMMD-1 protein, MURR 1 protein, COMMD1, COMM domain-containing protein 1 protein, COMMD-1, COMMD 1, COMMD 1 protein, COMM protein, COMMD 1 protein|
Coomassie Blue stained SDS-PAGE of COMMD1 protein (His tag) (80R-1392)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-190 amino acids: MGSSHHHHHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN|
|Grade & Purity||> 90% pure|
|Molecular Weight||23.3 kDa (210aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||COMMD1, also known as copper metabolism MURR1 domain-containing protein 1, is a 190 amino acid protein responsible for inhibition of TNF-induced NFkB p50 and has a suggested role in facilitation of biliary copper excretion within hepatocytes. High expression is found in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. This protein interacts directly with COMMD6 and ATP7B. Recombinant human COMMD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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