Complement C1q protein (32R-AC049)
Purified Complement C1q protein isolated from human plasma
Overview
Overview
| Synonyms | C1q protein |
|---|---|
| Species | Human |
| Protein Type | Native |
Specifications
| Source | Human plasma |
|---|---|
| Grade & Purity | > 96% pure |
| Molecular Weight | 410 kDa |
| Form & Buffer | Lyophilized from 0.01M Na2EDTA, pH 7.5, with 0.3M NaCl. |
Storage & Safety
| Storage | Store at 4 deg C. |
|---|---|
| Contaminants | None detected by SDS PAGE analysis |
General Information
| Biological Significance | Complement C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin.The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity. |
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