Complement C3 protein (32C-CP1036U)

Purified Complement C3 protein isolated from human plasma

Synonyms C3 protein
Species Human
Protein Type Native

Specifications

Source Human serum/plasma
Grade & Purity > 98% pure
Molecular Weight 185 kDa
Form & Buffer Frozen liquid in PBS, pH 7.2.

Usage & Assay Information

Bioactivity 13,200 units/mg

Storage & Safety

Storage Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles.
Biohazard Information Donor samples were tested and found to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

General Information

Biological Significance Native human C3 is a naturally glycosylated polypeptide containing two disulfide-linked chains. C3 is central to the activation of all three pathways of complement activation. Initiation of each pathway generates proteolytic enzyme complexes (C3 convertases) which are bound to the target surface. These enzymes cleave a peptide bond in C3 releasing the anaphylatoxin C3a and activating C3b. For a brief time (~60 us) this nascent C3b is capable of reacting with and covalently coupling to hydroxyl groups on the target surface.

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Availability: In stock

Price: €326.29
Size: 250 ug
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