Complement Factor B (30C-CP2036U)
Purified native Human Complement Factor B
Overview
Overview
| Synonyms | Native CFB |
|---|---|
| Species | Human |
| Protein Type | Native |
| Applications | User optimized |
Specifications
| Source | Human serum/plasma |
|---|---|
| Grade & Purity | > 98% pure |
| Molecular Weight | 93 kDa |
| Form & Buffer | Supplied as a liquid in PBS, pH 7.2, no preservatives added, |
| Concentration | 1.0 mg/ml |
Usage & Assay Information
| Bioactivity | 4, 700 U/mg - 100 % of factor B activity in NHS on a mg/mg basis |
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Storage & Safety
| Storage | Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles. |
|---|---|
| Biohazard Information | Donor samples were tested and found to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. |
General Information
| Biological Significance | Complement factor B is a glycosylated protein composed of a single 93,000 Da polypeptide chain. It is an essential component of the alternative pathway of complement activation and is found in plasma at approximately 200 ug/mL. In the presence of Mg++ factor B binds to C3b and the C3b,B complex can be activated by factor D, a serine protease that circulates as an active trypsin-like serine protease. |
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