Complement factor H antibody (10R-7448)

Mouse monoclonal Complement factor H antibody

Synonyms Monoclonal Complement factor H antibody, Anti-Complement factor H antibody, Complement H antibody, Factor H antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen Complement factor H antibody was raised in Mouse using Protein purified from Human plasma as the immunogen.

Images

Western blot analysis using Complement factor H antibody (10R-7448)

Specifications

Host Mouse
Clone 34F12
Isotype IgG1 kappa
Method of Purification Complement factor H antibody was purified by affinity chromatography.
Form & Buffer Supplied in PBS buffer (without mg2+ and Ca2+), pH 7.4, 150mM NaCl and 50% glycerol.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:1000-2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles..

General Information

Biological Significance The complement system is a crucial component of the innate immunity against microbial infection. Complement factor H, a 155 kDaplasma glycoprotein, is an essential regulatory protein that plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase and acts as a cofactor for the factor Imediated proteolyticinactivation of C3b. In addition, factor H has multiple physiological activities 1) acts as an extracellularmatrix component, 2) binds to cellular receptors of the integrintype, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. Complement factor H has revealed an association with two different renal diseases, glomerulonephritisand atypical hemolytic uremicsyndrome (aHUS).

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Images

  • Western blot analysis using Complement factor H antibody (10R-7448) |

Availability: In stock

Price: €257.67
Size: 100 ul
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