CRADD protein (His tag) (80R-1078)
Purified recombinant Human CRADD protein
|Synonyms||RIP associated ICH1/CED3 homologous protein with death domain protein, Caspase and RIP adapter with death domain protein, CRADD protein, MGC9163 protein, Caspase and RIP adapter with death domain CASP2 and RIPK1 domain containing adaptor with death domain protein, , Death adaptor molecule RAIDD protein, RIP associated protein with a death domain protein, Death domain containing protein CRADD protein, RAIDD protein|
Coomassie Blue stained SDS-PAGE of CRADD protein (His tag) (80R-1078)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-199 amino acids: MGSSHHHHHH SSGLVPRGSH MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLMLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE|
|Grade & Purity||> 95% pure|
|Molecular Weight||24.9 kDa (219aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CRADD is a 22 kDa, widely-expressed cytosolic adaptor protein. CRADD is a death domain (CARD/DD) containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. Recombinant CRADD protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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