CRP protein (30-1906)
Native human CRP protein
Overview
Overview
| Synonyms | Human CRP protein, Native CRP protein, Human C Reative protein, C-RP, C-Reactive protein |
|---|---|
| Species | Human |
| Protein Type | Native |
Specifications
| Source | Human pleural/ascitic fluid or plasma |
|---|---|
| Grade & Purity | > 95% pure |
| Form & Buffer | Supplied as liquid in 20 mM Tris, pH 8.0, 0.3 M NaCl, 0.05% sodium azide. |
Storage & Safety
| Storage | Store at 4 deg C. |
|---|---|
| Biohazard Information | Blood sample from the tissue donor was tested and found negative for HBsAg, HIV-1 and HIV-2 antibodies, and HCV. |
General Information
| Product Use | This CRP protein is suitable for use as an immunogen for antisera production, tracer for iodination, and as a standard in immunoassays |
|---|---|
| Biological Significance | C-reactive protein (CRP) is a member of the pentraxin family of proteins. It is a ring-shaped, pentameric protein found in blood plasma. Levels of CRP rise in response to inflammation. Its physiological function is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) which in turn activates the complement system via the C1Q complex. |
| Implications in Disease | CRP is elevated in acute inflammatory conditions such as bacterial and viral infections, rheumatoid arthritis, and various collagen related diseases. Levels of CRP are screened and monitored in cases of acute myocardial infarction, tissue injury and some malignant disorders. |
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