CtBP1 protein (30R-1495)
Purified recombinant Human CtBP1 protein
|Synonyms||CtBP 1, CtBP-1 protein, CtBP-1, CTBP protein, C-terminal-binding protein 1 isoform 1 C terminal binding protein 1 protein, CTBP1 protein, CtBP 1 protein, MGC104684., CtBP1, BARS protein|
Coomassie Blue stained SDS-PAGE of CtBP1 protein (30R-1495)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-440 amino acids: MGSSHLLNKG LPLGVRPPIM NGPLHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV PAASVEETAD STLCHILNLY RRATWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG VERALGLQRV STLQDLLFHS DCVTLHCGLN EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT HWASMDPAVV HPELNGAAYR YPPGVVGVAP TGIPAAVEGI VPSAMSLSHG LPPVAHPPHA PSPGQTVKPE ADRDHASDQL|
|Grade & Purity||> 90% pure|
|Molecular Weight||47.5 kDa (440aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 100mM NaCl and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||C-terminal-binding protein 1 isoform 1, also known as CtBP1, is expressed from embryo to adult. This protein binds to the C-terminus of adenovirus E1A. It is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. Also, CtBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Recombinant human CtBP1 was expressed in E. coli and purified by using conventional chromatography techniques.|
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