Cxcl12 protein (80R-4304)

Purified Recombinant Cxcl12 protein (His tagged)

Synonyms Pbsf protein, Scyb12 protein, Sdf1 protein, Tlsf protein, Tpar1 protein
Species Mouse
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS-PAGE analysis using Cxcl12 protein (His tag) (80R-4304)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 22-89 aa: MGSSHHHHHH SSGLVPRGSH MGSKPVSLSY RCPCRFFESH IARANVKHLK ILNTPNCALQ IVARLKNNNR QVCIDPKLKW IQEYLEKALN K
Expression System E.coli
Grade & Purity > 95% pure
Molecular Weight 10.4 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in PBS buffer (pH 7.4) containing 10% glycerol
Concentration 250 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage, aliquot and store at -20 or -70 deg C. Avoid repeat freeze/thaw cycles

General Information

Biological Significance Cxcl12 also known as stromal cell-derived factor 1 isoform alpha. This protein acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. This protein inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Cxcl12 protein plays a protective role after myocardial infarction. It induces down-regulation and internalization of ACKR3 expressed in various cells. Recombinant mouse Cxcl12, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques

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Images

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SDS-PAGE analysis using Cxcl12 protein (His tag) (80R-4304)



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Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: €275.66
Size: 20 ug
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