Cyclin D1 antibody (70R-13838)

Affinity purified Mouse polyclonal Human Cyclin D1 antibody

Synonyms Polyclonal Cyclin D1 antibody, Anti-Cyclin D1 antibody, Cyclin D 1 antibody, Cyclin D-1, BCL-1 oncogene antibdoy, PRAD1 oncogene antibody, Cyclin D1, Cyclin D 1, G1/S-specific cyclin-D1 antibody, Cyclin D-1 antibody
Applications WB
Immunogen Cyclin D1 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human Cyclin D1, different from the related Rabbit sequence by two amino acids, as the immunogen

Images

Western Blot analysis using Cyclin D1 antibody (70R-13838)

Lane 1: MCF-7 Cell Lysate; Lane 2: Hela Cell Lysate; Lane 3: MM231 Cell Lysate; Lane 4: MM453 Cell Lysate; Lane 5: HT1080 Cell Lysate

Specifications

Host Rabbit
Isotype IgG
Method of Purification Cyclin D1 antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance Bcl1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclin-dependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of Bchronic lymphocytic leukemia (BCLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma.

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Images

  • <div><font face=Calibri size=2>Western Blot analysis using Cyclin D1 antibody (70R-13838)</font></div>     | Lane 1: MCF-7 Cell Lysate; Lane 2: Hela Cell Lysate; Lane 3: MM231 Cell Lysate; Lane 4: MM453 Cell Lysate; Lane 5: HT1080 Cell Lysate

Availability: In stock

Price: €208.59
Size: 100 ug
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