Polyclonal Cyclin E antibody, Anti-Cyclin E antibody, Cyclin E1 antibody, CyclinE antibody, Cyclin Et antibody, Cyclin Es antibody, CCNE1 antibody, CCNE antibody, G1/S specific cyclin E antibody
Specificity
Human cyclin E
Cross Reactivity
To be determined by end-user
Applications
ELISA, IP, WB
Immunogen
Cyclin E antibody was raised in rabbit using KLH conjugated peptide corresponding to a region near the carboxy terminus of human cyclin E as the immunogen.
Store at -20 deg C. Aliquot and freeze at -20 deg C or below for long term storage. This product is stable for several weeks at 4 deg C as an undiluted liquid. Dilute only prior to immediate use. Avoid repeated freeze/thaw cycles.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
General Information
Biological Significance
Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase. The Cyclin E/CDK2 complex phosphorylates p27Kip1 (an inhibitor of Cyclin D), tagging it for degradation, thus promoting expression of Cyclin A, allowing progression to S phase.