Polyclonal Cyclin E antibody, Anti-Cyclin E antibody, CCNE antibody, Cyclin Es antibody, G1/S specific cyclin E antibody, CyclinE antibody, CCNE1 antibody, Cyclin E1 antibody, Cyclin Et antibody
Specificity
Human
Cross Reactivity
Mouse
Applications
IF, IP, Kinase Assay, WB
Immunogen
Cyclin E antibody was raised in rabbit using a synthetic peptide derived from the c-terminus of human cyclin E as the immunogen.
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
General Information
Biological Significance
Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation
of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.