Aliquot and store at -20 or -70 deg C. Avoid repeated freeze thaw cycles.
General Information
Biological Significance
Cyr61 is a secreted heparin binding protein, encoded by a growth factor-inducible immediate-early gene, that associates with the extracellular matrix and connective tissue. As an angiogenic inducer, Cyr61 binds to the cell surface receptor Integrin aV/b3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells.
Expression
Expression of Cyr61 is elevated during vessel growth, wound healing and chondrocyte differentiation.
Implications in Disease
Cyr61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.