CYR61 antibody (70R-51957)

Affinity purified rabbit polyclonal CYR61 antibody

Synonyms Human CYR61 antibody, Polyclonal CYR61 antibody, IGFBP10 antibody, IGF binding protein 10 antibody, IBP10 antibody, CCN family member 1 antibody, CCN1 antibody
Specificity Human
Applications IHC, WB
Immunogen CYR61 antibody was raised in rabbit using recombinant human CYR61 protein as the immunogen.

Specifications

Host Rabbit
Isotype IgG
Method of Purification Affinity purified
Form & Buffer Supplied in PBS pH 7.3 with 0.02% sodium azide, 50% glycerol.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:500-1:2000, IHC: 1:50-1:200

Storage & Safety

Storage Aliquot and store at -20 or -70 deg C. Avoid repeated freeze thaw cycles.

General Information

Biological Significance Cyr61 is a secreted heparin binding protein, encoded by a growth factor-inducible immediate-early gene, that associates with the extracellular matrix and connective tissue. As an angiogenic inducer, Cyr61 binds to the cell surface receptor Integrin aV/b3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells.
Expression Expression of Cyr61 is elevated during vessel growth, wound healing and chondrocyte differentiation.
Implications in Disease Cyr61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

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Availability: In stock

Price: €330.47
Size: 100 ug
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