Cytokeratin Pan antibody (10R-2096)

Mouse monoclonal Cytokeratin Pan antibody

Synonyms Monoclonal Cytokeratin Pan antibody, Anti-Cytokeratin Pan antibody
Cross Reactivity Human
Applications ELISA, IF, IHC, WB
Immunogen Cytokeratin Pan antibody was raised in Mouse using a purified recombinant fragment of CK5 expressed in E. coli as the immunogen.

Images

Immunofluorescent staining using Western Blot analysis using Cytokeratin Pan antibody (10R-2096) (Cytokeratin Pan antibody)

Immunofluorescence staining of methanol-fixed Eca-109 (left) and HepG2 (right) cells showing cytoplasmic localization.

Specifications

Host Mouse
Clone 7H8C4
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors.

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Images

  • Immunofluorescent staining using Western Blot analysis using Cytokeratin Pan antibody (10R-2096) (Cytokeratin Pan antibody) | Immunofluorescence staining of methanol-fixed Eca-109 (left) and HepG2 (right) cells showing cytoplasmic localization.
  • Western Blot analysis using Cytokeratin Pan antibody (10R-2096) | Western Blot showing CK antibody used against truncated CK5 recombinant protein.
  • Immunohistochemical staining using Cytokeratin Pan antibody (10R-2096) | Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma (A),normal hepatocyte (B), colon adenocacinoma?, normal stomach tissue (D), showing cytoplasmic and membrane localization using CK antibody with DAB staining.
  • Immunohistochemical staining using Cytokeratin Pan antibody (10R-2096) | Immunohistochemical analysis of paraffin-embedded human Skin tissues using CK antibody

Availability: In stock

Price: €285.10
Size: 100 ul
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