DBH antibody (70R-14963)
Sheep polyclonal DBH antibody
Overview
Overview
| Synonyms | Polyclonal DBH antibody, Anti-DBH antibody, Dopamine beta-Hydroxylase antibody |
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| Applications | WB |
Images
Western Blot analysis using DBH antibody (70R-14963)
Western blot of human adrenal medulla lysate showing specific immunolabeling of ~75k DBH protein
Specifications
| Host | Sheep |
|---|---|
| Method of Purification | DBH antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in liquid form in 10 mM HEPES buffer (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:1000 |
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General Information
| Biological Significance | DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. |
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