DHH protein (His tag) (80R-1075)
Purified recombinant Human DHH protein
|Synonyms||Desert hedgehog protein precursor., desert hedgehog preproprotein Desert hedgehog protein, Desert hedgehog (Drosophila) homolog protein, Desert hedgehog homolog (Drosophila) protein, DHH protein, HHG-3 protein, Desert hedgehog protein N-product protein, Drosophila protein, MGC35145 protein|
Coomassie Blue stained SDS-PAGE of DHH protein (His tag) (80R-1075)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||23-198 amino acids: MGSSHHHHHH SSGLVPRGSH MCGPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG|
|Grade & Purity||> 95% pure|
|Molecular Weight||22 kDa (197aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in20mM MES, pH 5.5, containing 0.5mM DTT, and 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||DHH belongs to the hedgehog family. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N- terminal domain is the active species in both local and long-range signaling, whereas the C-terminal domain has no signaling activity. This protein is produced by Sertoli cells and may be involved in both male gonadal differentiation and perineurial development. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. Recombinant DHH protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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