Dkk1 protein (His tag) (80R-1115)
Purified recombinant Human Dkk1 protein
|Synonyms||Dkk 1, Dickkopf-1 protein, DKK1, Dickkopf related protein 1 protein, Dickkopf 1 like protein, Dickkopf-related protein 1 Dickkopf 1 protein, DKK 1 protein, hDkk 1 protein, Dkk-1 protein, Dkk 1 protein, Dickkopf homolog 1 protein, SK protein, Dkk1, hDkk-1 protein, Dkk-1|
Coomassie Blue stained SDS-PAGE of Dkk1 protein (His tag) (80R-1115)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||32-266 amino acids: ADPTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRHSG RLVPRGSHHH HHH|
|Expression System||Hi-5 cells|
|Grade & Purity||> 85% pure|
|Molecular Weight||27.8 kDa (253 aa) (On SDS-PAGE under denatured condition, apparent molecular weight of glycosylated rhDkk-1 protein will be appeared at approximately 40 kDa)|
|Form & Buffer||Supplied as a liquid in PBS, pH 7.4, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Dickkopf-related protein 1, also known as Dkk-1, is a member of the Dkk protein family including Dkk-1, 2, 3 and -4. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated level of Dkk-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Recombinant human Dkk-1 protein, fused to His-tag at C-terminus, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography.|
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