DL1 antibody (PE) (61R-1345)
Armenian Hamster monoclonal Dll1 antibody (PE)
Overview
Overview
| Synonyms | Monoclonal DL1 antibody, Anti-DL1 antibody, DL-1, DL 1 antibody, DL1, DL-1 antibody, DL 1, DL1 antibody |
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| Applications | FC, ICC |
| Assay Information | A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest |
Images
Flow Cytometric analysis using DL1 antibody (PE) (61R-1345)
Staining of CD8+CD11c+ C57BL/6 splenocytes with 0.125 ug of Armenian Hamster IgG Isotype Control (PE) (blue histogram) or 0.125 ug of DLL1 antibody (PE) (purple histogram). Total viable cells were used for analysis.
Specifications
| Host | Hamster |
|---|---|
| Clone | HMD1-5 |
| Isotype | IgG |
| Tag/Conjugate | PE |
| Form & Buffer | Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
| Concentration | 200 ug/ml |
Usage & Assay Information
| Usage Recommendations | FC: = 0.5 ug/test |
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Storage & Safety
| Storage | Store at 2-8 deg C. Do not freeze. Protect from light. |
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General Information
| Biological Significance | The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor, Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis. |
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