DNA polymerase gamma antibody (70R-12532)
Affinity purified Rabbit polyclonal DNA polymerase gamma antibody
Overview
Overview
| Synonyms | Polyclonal DNA polymerase gamma antibody, Anti-DNA polymerase gamma antibody, PolG-alpha antibody, FLJ27114 antibody, MIRAS antibody, MTDPS4A antibody, PEO antibody, POLG1 antibody, SANDO antibody, MTDPS4B antibody, MDP1 antibody, mitochondrial DNA polymerase catalytic subunit antibody, PolG catalytic subunit antibody, POLG antibody, POLGA antibody, SCAE antibody, DNA polymerase subunit gamma-1 antibody |
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| Cross Reactivity | Human |
| Applications | ICC, IF, IHC-P, WB |
| Immunogen | DNA polymerase gamma antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 779 and 1231 of DNA polymerase gamma |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | DNA polymerase gamma antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 140 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 0.67 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:500, ICC:1:100-1:500, IHC-P: 1:100-1:500, WB: 1:1000-1:10000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). |
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