DPC4 antibody (10R-7899)
Mouse monoclonal DPC4 antibody
Overview
Overview
| Synonyms | Monoclonal DPC4 antibody, Anti-DPC4 antibody, DPC4, DPC-4, DPC 4, DPC-4 antibody, DPC 4 antibody, SMAD4 antibody |
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| Applications | ICC, WB |
| Immunogen | DPC4 antibody was raised in mouse using recombinant human Smad4 (DPC4) as the immunogen |
Images
Western blot analysis using DPC4 antibody (10R-7899)
Lane 1: Rat Brain Tissue Lysate, Lane 2: Rat Brain Tissue Lysate
Specifications
| Host | Mouse |
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| Clone | IMD-89 |
| Isotype | IgG1 |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. |
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