DPYSL5 protein (80-1532)
Purified Recombinant DPYSL5 protein (His tag)
Overview
Overview
| Synonyms | BMP binding endothelial regulator protein, BMP-binding endothelial regulator precursor protein protein, BMPER protein, bone morphogenetic protein-binding endothelial cell precursor-derived regulator protein, CRIM3 protein, crossveinless 2 protein, crossveinless-2 protein, CV-2 protein, CV2 protein, Q8N8U9 protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE, WB |
| Assay Information | Currently being validated in ELISA |
Specifications
| Residues | 1-564 aa |
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| Expression System | E.coli |
| Grade & Purity | > 85% pure |
| Method of Purification | DPYSL5 protein was purified using proprietary chromatographic techniques |
| Molecular Weight | 65 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in 50 mM Tris buffer, pH 8.0, 150 mM NaCL, 10% glycerol, 1 mM EDTA and 2 mM DTT |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -70 deg c for long term storage. Avoid repeat freeze/thaw cycles |
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General Information
| Product Use | Purified Recombinant DPYSL5 protein for use in SDS-PAGE and Western Blot. |
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| Biological Significance | DPYSL5 is a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. DPYSL5 is a member of the collapsin response mediator protein family (CRMPs) which are involved in an autoimmune disease associated with small cell lung carcinoma. Members of the CRMP family, such as DPYSL5, are believed to play a role in growth cone guidance during neural development. |
| Expression | DPYSL5 is highly expressed in lung, and brain and also in primary chondrocytes. |
| Implications in Disease | Defects in DPYSL5 are the cause of diaphanospondylodysostosis (DSD), a rare, recessively inherited, perinatal lethal skeletal disorder, the characteristics of which include a small chest, abnormal vertebral segmentation, as well as craniofacial abnormalities. |
| Sequence Information | DPYSL5 is composed of 564 amino acids with a molecular weight of 65 kDa. CV2 contains 1 TIL (trypsin inhibitory-like) domain, 5 VWFC domains and 1 VWFD domain. |
| Post-Translational Modifications | Glycosylation of DPYSL5 occurs at Asn116, Asn247, Asn255, Asn318, Asn441 |
| Database Links | Entrez Gene: 168667 Human, Omim: 608699 Human, SwissProt: Q8N8U9 Human, Unigene: 660998 Human, Protein ID: AAH02874.1 |
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