dUTPase antibody (70R-13712)
Affinity purified Rabbit polyclonal dUTPase antibody
Overview
Overview
| Synonyms | Polyclonal dUTPase antibody, Anti-dUTPase antibody, Deoxyuridine triphosphate nucleotidohydrolase antibody |
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| Applications | IHC-P, WB |
| Immunogen | dUTPase antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human dUTPase, different from the related rat and Rabbit sequences by two amino acids, as the immunogen |
Images
Immunohistochemical staining using dUTPase antibody (70R-13712)
Immunohistochemistry of paraffin embedded section of Human Intestinal Cancer Tissue
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | dUTPase antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | dUTPase is responsible for maintaining low ntracellular levels of dUTP, thus preventing the incorporation of dUTP into DNA. DUTPase ctivity/expression can be down-regulated using siRNA specifically targeted to dUTPase mRNA and UTPase plays a role in DNA nucleotide metabolism. This protein, present predominantly in the ytoplasm, contains 252 amino acids with a Mr of 26, 704. It exhibits 35% identity with the E. coli UTPase and 53% identity with the Saccharomyces cerevisiae enzyme. The nuclear and mitochondrial orms of dUTPase are encoded by the same gene with isoform-specific transcripts arising through the se of alternative 5-prime exons. Human dUTPase exhibits 92% identity with rat. Moreover, this nzyme has profound effects on the efficacy of agents that target thymidylate biosynthesis. |
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