dUTPase antibody (70R-13712)

Affinity purified Rabbit polyclonal dUTPase antibody

Synonyms Polyclonal dUTPase antibody, Anti-dUTPase antibody, Deoxyuridine triphosphate nucleotidohydrolase antibody
Applications IHC-P, WB
Immunogen dUTPase antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human dUTPase, different from the related rat and Rabbit sequences by two amino acids, as the immunogen

Images

Immunohistochemical staining using dUTPase antibody (70R-13712)

Immunohistochemistry of paraffin embedded section of Human Intestinal Cancer Tissue

Specifications

Host Rabbit
Isotype IgG
Method of Purification dUTPase antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance dUTPase is responsible for maintaining low ntracellular levels of dUTP, thus preventing the incorporation of dUTP into DNA. DUTPase ctivity/expression can be down-regulated using siRNA specifically targeted to dUTPase mRNA and UTPase plays a role in DNA nucleotide metabolism. This protein, present predominantly in the ytoplasm, contains 252 amino acids with a Mr of 26, 704. It exhibits 35% identity with the E. coli UTPase and 53% identity with the Saccharomyces cerevisiae enzyme. The nuclear and mitochondrial orms of dUTPase are encoded by the same gene with isoform-specific transcripts arising through the se of alternative 5-prime exons. Human dUTPase exhibits 92% identity with rat. Moreover, this nzyme has profound effects on the efficacy of agents that target thymidylate biosynthesis.

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Images

  • Immunohistochemical staining using dUTPase antibody (70R-13712) | Immunohistochemistry of paraffin embedded section of Human Intestinal Cancer Tissue

Availability: In stock

Price: €220.86
Size: 100 ug
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