EEF1E1 protein (His tag) (80R-1779)
Purified recombinant Human EEF1E1 protein
|Synonyms||EEF1E1-10 protein, Eukaryotic translation elongation factor 1 epsilon-1 protein, AIMP3 protein, P18 protein, EEF1E1 10, EEF1E1, EEF1E1-10, EEF1E1 10 protein|
Coomassie Blue stained SDS-PAGE of EEF1E1 protein (His tag) (80R-1779)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-174 amino acids: MGSSHHHHHH SSGLVPRGSH MAAAAELSLL EKSLGLSKGN KYSAQGERQI PVLQTNNGPS LTGLTTIAAH LVKQANKEYL LGSTAEEKAI VQQWLEYRVT QVDGHSSKND IHTLLKDLNS YLEDKVYLTG YNFTLADILL YYGLHRFIVD LTVQEKEKYL NVSRWFCHIQ HYPGIRQHLS SVVFIKNRLY TNSH|
|Grade & Purity||> 95% pure|
|Molecular Weight||21.9 kDa (194aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||EEF1E1, also known as, eukaryotic translation elongation factor 1 epsilon-1, shares sequence similarity with the amino-terminal ends of the Beta and Gamma subunits of EF-1. By specifically interacting with MetRS, this protein binds to a macromolecular tRNA synthtase complex that catalyzes the ligation of specific amino acids to their cognate tRNAs. Upon DNA damage, it translocates to the nucleus where it interacts with ATM and ATR, resulting in p53 activation. Recombinant human EEIF1E1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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