Endoglin protein (30R-2630)
Purified recombinant Mouse Endoglin protein
Overview
Overview
| Synonyms | FLJ41744 protein, CD105 protein, END protein, HHT1 protein, ENG protein, Endoglin protein, ORW1 protein, ORW protein |
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| Species | Mouse |
| Protein Type | Recombinant |
Specifications
| Expression System | Sf-9 insect cells |
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| Grade & Purity | > 95% pure |
| Method of Purification | Endoglin protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 75-85 kDa |
| Form & Buffer | Supplied in lyophilized form from sterile solution without additives |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF- beta1 receptor complex. It thus may be involved in the binding of TGF- beta1, TGF- beta3, Activin-A, BMP-2, and BMP-7. It has been postulated that Endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. |
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