Ephrin B2 protein (80R-4359)
Purified Recombinant Ephrin B2 protein (His tagged)
Overview
Overview
| Synonyms | Efnb2 protein, ELF-2 protein, Epl5 protein, Eplg5 protein, Htk-L protein, LERK-5 protein, Lerk5 protein, NLERK-1 protein |
|---|---|
| Species | Mouse |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Specifications
| Residues | 29-232 aa: RSIVLEPIYW NSSNSKFLPG QGLVLYPQIG DKLDIICPKV DSKTVGQYEY YKVYMVDKDQ ADRCTIKKEN TPLLNCARPD QDVKFTIKFQ EFSPNLWGLE FQKNKDYYII STSNGSLEGL DNQEGGVCQT RAMKILMKVG QDASSAGSAR NHGPTRRPEL EAGTNGRSST TSPFVKPNPG SSTDGNSAGH SGNNLLGSEV ALFALEHHHH HH |
|---|---|
| Expression System | Insect cells |
| Grade & Purity | > 90% pure |
| Molecular Weight | 23.4 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 500 ug/ml |
Storage & Safety
| Storage | Store at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 deg C. Avoid repeated freezing and thawing cycles. |
|---|---|
| Endotoxin Levels | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
General Information
| Biological Significance | EFNB2, also known as ephrin-B2, is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. It binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. It may play a role in constraining the orientation of longitudinally projecting axons. |
|---|
Reviews
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product