ERBB2 antibody (10R-2257)

Mouse monoclonal ERBB2 antibody

Synonyms Monoclonal ERBB2 antibody, Anti-ERBB2 antibody, c-neu antibody, erbb2 antibody, Her-2 Neu antibody, her-2/neu antibody, Her2 antibody, Her2 Neu antibody, Her2/Neu antibody, herstatin antibody, neu oncogene antibody, oncogene ngl antibody, p185erbb2 antibody, tkr1 antibody, tyrosine kinase r antibody, ERBB2, ERBB 2, ERBB-2, ERBB 2 antibody, ERBB-2 antibody
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen ERBB2 antibody was raised in Mouse using a purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. coli as the immunogen.

Images

Flow Cytometric assay using Western Blot analysis using ERBB2 antibody (10R-2257) (ERBB2 antibody)

FC analysis of MCF-7 cells using ERBB2 antibody (green) and negative control (purple).

Specifications

Host Mouse
Clone 6C2
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers.

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Images

  • Flow Cytometric assay using Western Blot analysis using ERBB2 antibody (10R-2257) (ERBB2 antibody) | FC analysis of MCF-7 cells using ERBB2 antibody (green) and negative control (purple).
  • Western Blot analysis using ERBB2 antibody (10R-2257) | Western Blot showing ERBB2 antibody used against SKBR3 (1) and MCF-7 (2) cell lysate.
  • Immunohistochemical staining using ERBB2 antibody (10R-2257) | Immunohistochemical analysis of paraffin-embedded galactophore tumour using ERBB2 antibody with DAB staining

Availability: In stock

Price: €282.21
Size: 100 ul
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