ERBB2 antibody (10R-8110)

Mouse monoclonal ERBB2 antibody

Synonyms Monoclonal ERBB2 antibody, Anti-ERBB2 antibody, c-neu antibody, erbb2 antibody, Her-2 Neu antibody, her-2/neu antibody, Her2 antibody, Her2 Neu antibody, Her2/Neu antibody, herstatin antibody, neu oncogene antibody, oncogene ngl antibody, p185erbb2 antibody, tkr1 antibody, tyrosine kinase r antibody, ERBB 2 antibody, ERBB-2 antibody, ERBB 2, ERBB-2, ERBB2
Specificity Reacts equally well with the wild type as well as the mutant (oncogenic) form of the c-erbB-2/HER-2/neu protein, but preferentially recognizes the unphosphorylated form of this protein
Cross Reactivity Human, Monkey, Mouse, Rat
Applications IHC-F, IHC-P, IP, WB
Immunogen ERBB2 antibody was raised in Mouse using a synthetic peptide TAENPEYLGLDVPV corresponding to amino acid residues 1242-1255 of the C-terminus of the human c-erbB-2/HER-2/neu protein This sequence is identical in rat neu protein as the immunogen.

Images

Immunohistochemical staining using ERBB2 antibody (10R-8110)

Immunohistochemical staining of paraffin section of human Mamma tumor Her2Neu+ using ERBB2 antibody (10R-8110)

Specifications

Host Mouse
Clone 3B5
Isotype IgG1
Form & Buffer Supplied in PBS containing 0.09% sodium azide

Usage & Assay Information

Usage Recommendations IHC: 1:100-1:1000, WB: 1:250-1:1000

General Information

Biological Significance In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

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Images

  • Immunohistochemical staining using ERBB2 antibody (10R-8110) | Immunohistochemical staining of paraffin section of human Mamma tumor Her2Neu+ using ERBB2 antibody (10R-8110)
  • Immunohistochemical staining using ERBB2 antibody (10R-8110) | Immunohistochemical staining of paraffin section of human breast carcinoma using ERBB2 antibody (10R-8110)

Availability: In stock

Price: €345.19
Size: 100 ug
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