Erk1/2/MAPK antibody (20R-1446)

Rabbit polyclonal Erk1/2/MAPK antibody

Synonyms Polyclonal Erk1/2/MAPK antibody, Anti-Erk1/2/MAPK antibody, Erk1/Erk2/MAPK antibody, Erk1 and 2 and MAPK antibody, Erk1/Erk2/MAPK, Erk1/2/MAPK, Erk1-2-MAPK antibody, Erk1 and 2 and MAPK, Extracellular signal regulated kinase 1 and 2 antibody
Cross Reactivity Human, Mouse, Rat, Sheep, Chicken
Applications IHC, IP, WB
Immunogen Erk1/2/MAPK antibody was raised in Rabbit using synthetic peptide derived from rat p42 MAP kinase as the immunogen.

Specifications

Host Rabbit
Isotype IgG
Method of Purification Erk1/2/MAPK antibody was purified by affinity purification.
Form & Buffer Supplied in PBS buffer, pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations IP: 20-40 ug/ml, IHC: 20-40 ug/ml, WB: 0.5-4 ug/ml

Storage & Safety

Storage Store at -20 deg C. For long-term storage, aliquot and freeze at -70 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The extracellular signal regulated kinase 1 and 2 (Erk1 and Erk2) are closely related mitogen activated protein (MAP) kinases that are activated through the extracellular stimulation by many growth factors, mitogens and differentiation promoting agents via a protein kinase cascade. Erk1/2 are activated approximately 1000 fold by phosphorylation of neibouring threonine and tyrosine residues by Mek1 and Mek2. Both sites must be phosphorylated for maximum activity. Erk1/2 kinases are ubiquitously distributed in the nervous system, as well as a broad range of cells and tissues. These two kinases represent proximal kinases in the classical MAP kinase cascade pathway which links growth and differentiation signals at the cell surface (through tyrosine kinase) with transcription in the nucleus.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: €478.53
Size: 100 ug
OR
Shipping
View Our Distributors