Polyclonal Erk1/2/MAPK antibody, Anti-Erk1/2/MAPK antibody, Erk1/Erk2/MAPK antibody, Erk1 and 2 and MAPK antibody, Erk1/Erk2/MAPK, Erk1/2/MAPK, Erk1-2-MAPK antibody, Erk1 and 2 and MAPK, Extracellular signal regulated kinase 1 and 2 antibody
Cross Reactivity
Human, Mouse, Rat, Sheep, Chicken
Applications
IHC, IP, WB
Immunogen
Erk1/2/MAPK antibody was raised in Rabbit using synthetic peptide derived from rat p42 MAP kinase as the immunogen.
Store at -20 deg C. For long-term storage, aliquot and freeze at -70 deg C. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
The extracellular signal regulated kinase 1 and 2 (Erk1 and Erk2) are closely related mitogen activated protein (MAP) kinases that are activated through the extracellular stimulation by many growth factors, mitogens and differentiation promoting agents via a protein kinase cascade. Erk1/2 are activated approximately 1000 fold by phosphorylation of neibouring threonine and tyrosine residues by Mek1 and Mek2. Both sites must be phosphorylated for maximum activity. Erk1/2 kinases are ubiquitously distributed in the nervous system, as well as a broad range of cells and tissues. These two kinases represent proximal kinases in the classical MAP kinase cascade pathway which links growth and differentiation signals at the cell surface (through tyrosine kinase) with transcription in the nucleus.