ESE1 antibody (70R-12507)
Affinity purified Rabbit polyclonal ESE1 antibody
Overview
Overview
| Synonyms | Polyclonal ESE1 antibody, Anti-ESE1 antibody, ESE-1 antibody, ERT antibody, E74-like factor 3 (ets domain transcription factor) antibody, ESE-1, ets domain transcription factor serine box (epithelial-specific) antibody, ELF3 antibody, ESE 1 antibody, epithelium-restricted Ets protein ESX antibody, E74-like factor 3 (ETS domain transcription factor serine box epithelial-specific) antibody, EPR-1 antibody, ETS-related transcription factor Elf-3 antibody, ESE-1 antibody, ESX antibody, epithelial-restricted with serine box antibody, ESE 1, ESE1, epithelium-specific Ets transcription factor 1 antibody |
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| Cross Reactivity | Human |
| Applications | ICC, IF, IHC-P, WB |
| Immunogen | ESE1 antibody was raised in rabbit using a synthetic peptide corresponding to a region within amino acids 309 and 371 of ESE1 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | ESE1 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 41 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 1X PBS, 1% BSA, 20% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:500, ICC:1:100-1:500, IHC-P: 1:100-1:500, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. |
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